Publications 

Publications les plus récentes (2006- )

• Towards MRI contrast agents responsive to Ca(II) and Mg(II) ions: metal-induiced oligomerization of DOTA-biphosphontaes conjugates

  V. KUBICEK, T. VITHA, J. KOTEK, P. HERMANN, L. VANDER ELST, R.N. MULLER, I. LUKES, J.A. PETERS
  Contrast Med. Mol. Imaging, accepted (2010)

• Magnetic iron oxide nanoparticles for biomedical applications
  S. LAURENT, J.L. BRIDOT, L. VANDER ELST, R. MULLER,
  Future Medicinal Chemistry, accepted (2010)

• Development of magnetic chromatography to sort polydisperse nanoparticles in ferrofluids
  D. FORGE, Y. GOSSUIN, A. ROCH, S. LAURENT, L. VANDER ELST, R.N. MULLER
  Contrast Med. Mol. Imaging, accepted (2010)

• Iron oxide particles covered  with Hexapeptides Targeted to Phosphatidylserine as MR Biomarkers of Tumor Cell Death
  K.A. RADERMACHER, S. BOUTRY, S. LAURENT, L. VANDER ELST, I. MAHIEU, C. BOUZIN, J. MAGAT, V.GREGOIRE, O. FERON, R.N. MULLER, B.F. JORDAN, B. GALLEZ,
  Contrast Med. Mol. Imaging, accepted (2010)

• High quality and tuneable silica shell–magnetic core nanoparticles,
  C. Vogt, M. Toprak, M. Muhammed, S. Laurent, J. Bridot, et R. Muller,
  Journal of Nanoparticle Research. (Online first)

• Reduced blood brain barrier breakdown in P-selectin deficient mice following transient ischemic stroke: a future therapeutic target for treatment of stroke,
  A.Y. Jin, U.I. Tuor, D. Rushforth, J. Kaur, R.N. Muller, J.L. Petterson, S. Boutry, et P.A. Barber,
  BMC Neuroscience,  vol. 11, 2010, p. 12.

• Ultrasmall particle of iron oxide - RGD peptidomimetic conjugate: synthesis and characterization,
  Rerat V, Laurent S, Burtea C, Driesschaert B, Pourcelle V, Vander Elst L, Muller RN, Marchand-Brynaert J,
  Bioorg Med Chem Lett, 20(6), (2010), 1861-1865

• Synthesis and physicochemical characterization of Gd-C4-thyroxin-DTPA, a potential MRI contrast agent. Evaluation of its affinity for human serum albumin by proton relaxometry, NMR diffusometry and electrospray mass spectrometry.
  C. Henoumont, L. Vander Elst, S. Laurent, R.N. Muller,
  J. Phys.Chem.B (2010) 114, 3689-3697

• H-1 NMR relaxivity of aqueous suspensions of titanium dioxide nanoparticles coated with a gadolinium(III) chelate of a DOTA-monoamide with a phenylphosphonate pendant arm.
  REHOR I, KUBICEK V, KOTEK J., HERMANN P., LUKES I., SZAKOVA J., VANDER ELST L., MULLER R.N., PETERS J.A.
  J. Mater. Chem 19, (2009) 1494-1500

• How to perform accurate and reliable measurements of longitudinal and transverse relaxation times of MRI contrast media in aqueous solutions.
  C. Henoumont, S. Laurent, L. Vander Elst,
  Contrast Media Mol. Imaging, 4(6) (2009) 312-321

• Lanthanide Complexes for Magnetic Resonance and Optical Molecular Imaging
  S. LAURENT, L. VANDER ELST, R.N. MULLER,
  Q. J. Nucl. Med. Mol Imaging, 53 (2009), 586-603

• L’imagerie moléculaire, un nouvel outil multidisciplinaire de la recherche biomédicale, Laurent S, Burtea C, Boutry S,
  Elément, 3, 2009, 20-23..

• Molecular MRI of VCAM-1 expression in inflammatory lesions using a peptide-vectorized paramagnetic imaging probe.
  Burtea C, Laurent S, Port M, Lancelot E, Ballet S, Rousseaux O, Toubeau G, Vander Elst L, Corot C, Muller RN,
  J Med Chem, 52(15), (2009), 4725-4742.

• Peptidic targeting of phosphatidylserine for the MRI detection of apoptosis in atherosclerotic plaques
  Burtea C, Laurent S, Lancelot E, Ballet S, Murariu O, Rousseaux O, Port M, Vander Elst L, Corot C, Muller RN,
  Mol Pharm, (2009), 6(6):1903-19.

• How to quantify iron in an aqueous or biological matrix: a technical note.
  Boutry S, Forge D, Burtea C, Mahieu I, Murariu O, Laurent S, Vander Elst L, Muller RN,
  Contrast Media Mol Imaging, 4(6) (2009),299-304.

• R&D of novel medicinal materials for curing cancer: sugar modified Gd-DTPA MRI contrast agents and phospha sugar anti-cancer agents
  J. YAMASHITA, M. YAMASHITA, M. FUJIE, K. ASAI T. SUYAMA, S. ITO, V.K. REDDY, M. YAMADA, K. OGAWA, N. OZAKI, S. NAKAMURA, T. AOKI, G. YU, K. AOSHIMA, T. KATO, N. KAMIKAGE, K. KIYOFUJI, Y. TAKEHARA, H. SAKAHARA, H. TAKAYANAGI, T. OSHIKAWA, S. LAURENT, C. BURTEA, L. VANDER ELST, R.N. MULLER,
  Journal of Automation, Mobile Robotics & Intelligent Systems (JAMRIS), 3(4), (2009) 80-83

• Gd(III) complex of a monophosphinate-bis(phosphonate) DOTA analogue with a high relaxivity; Lanthanide(III) complexes for imaging and radiotherapy of calcified tissues.,
  VITHA T, KUBÍCEK V, KOTEK J, HERMANN P, VANDER ELST L, MULLER RN, LUKES I, PETERS JA.
  Dalton Trans. 7(17), 3204-3214. (2009)

• Produits de contraste en IRM
  S. LAURENT, L. VANDER ELST, R.N.MULLER,
  EMC (Elsevier Masson SAS, Paris), Radiologie et imagerie médicale –principes et technique –radioprotection, 35-236-A-10 (2009)

• Iron oxide based MR contrast agents: from chemistry to cell labeling,
  S. Laurent, S. Boutry, I. Mahieu, L. Vander Elst, et R.N. Muller,
  Current Medicinal Chemistry,  vol. 16, 2009, p. 4712-4727.

• In vivo detection of inflammation using pegylated iron oxide particles targeted at E-selectin: a multimodal approach using MR imaging and EPR spectroscopy,
  K.A. Radermacher, N. Beghein, S. Boutry, S. Laurent, L. Vander Elst, R.N. Muller, B.F. Jordan, et B. Gallez,
  Investigative Radiology,  vol. 44 No. 7, Jul. 2009, p. 398-404.

• Etude quantitative des interactions non covalentes entre l’albumine sérique humaine et les petites molécules. Apport de la spectrométrie de masse à l’imagerie moléculaire
  S. LAURENT, V. HENROTTE, L. VANDER ELST, R.N. MULLER,
  Chimie Nouvelle, vol 27, n°101, 15-23 (2009)

•  Relaxometric, Thermodynamic and Kinetic Studies of Lanthanide(III) Complexes of DO3A-based Propylphosphonate
  I. MAMEDOV, P. TABORSKY, P. LUBAL, S. LAURENT,  L. VANDER ELST,  H. MAYER, N.K. LOGOTHETIS, G. ANGELOWSKI,
  Eur. J. Inorg. Chem., 22, 3298 – 3306 (2009)

• Lanthanide complexes on Ag nanoparticles: Designing contrast agents for Magnetic Resonance Imaging
  T.S. SIDDIQUI, A. JANI, F. WILLIAMS, F. YAO, Y. ZAIM WADGHIRI, R.N. MULLER, L. VANDER ELST, S. LAURENT,
  J. Coll. Interface Sci., 337(1), 88-96 (2009)

• Contrast Agents for MRI: Recent Advances”
  S. LAURENT, L.VANDER ELST, R.N. MULLER
  dans “Encyclopedia of Magnetic Resonance”, eds R. K. Harris and R. Wasylishen, John Wiley: Chichester. DOI: 10.1002/9780470034590.emrstm1049. Publié le 15 Mars 2009.

• Identification of Peptide Ligands that Target Apoptotic Cells by Means of Specific Interactions with Phosphatidylserine. Applications to Molecular Imaging by MRI
  C. BURTEA, S. LAURENT, E. LANCELOT, S. BALLET, O. MURARIU, O. ROUSSEAUX, M. PORT, L. VANDER ELST, C. COROT, R.N. MULLER,
  Mol. Pharm., 6(6):1903-19 (2009). 

• Calix[4]arenes as Molecular Platforms for Potential High-field MRI Contrast Agents .
  D.T. SCHÜHLE, U. HANEFELD, J. SCHATZ, S. LAURENT, L. VANDER ELST, R.N. MULLER, M.C.A. STUART, J.A. PETERS,
  Chem. Eur. J., 15 (13), 3290-3296 (2009)

• Study of non covalent interactions between MRI contrast agents and human serum albumin by NMR diffusometry,
  C. Henoumont, L. Vander Elst, S. Laurent, R.N. Muller
  J. Biol. Inorg. Chem. 14(5) (2009) 683-691

• Synthèse et caractérisation du Gd-C4-thyroxin-DTPA, un nouvel agent de contraste potentiel pour l'IRM. Etude de son interaction non covalente avec l'albumine sérique humaine,
  C. Henoumont, L. Vander Elst, S. Laurent, R.N. Muller
  Ingénierie et Recherche Bioméd. (IRBM) 30(4) (2009) 197-200

• Optimised Synthetic Route for Tuneable Shell SiO2@Fe3O4 Core-Shell Nanoparticles
  C. Vogt, M.S. Toprak, J. Shi, N.F. Torres, B. Fadeel, S. Laurent, J.L. Bridot, R.N. Mller, et M. Muhammed,
  Materials Research Society Symposium Proceedings, (2008).

• An assessment of the potential relationship between the charge of Gd-DTPA complexes and the exchange rate of the water coordinated to the metal.
  Laurent S., Vander Elst L., Botteman F., Muller R.N.
  Eur. J. Inorg. Chem. , F.I., 2,597, 28 (2008) 4369-4379

• Lanthanide(III) complexes of bis(phosphonate) monoamide analogues of DOTA: bone-seeking agents for imaging and therapy
  Vitha T., Kubicek V., Herma,, P, Vander Elst L., Muller R.N., Kolar Z.I., Wolterkeek H.T., Breeman W.A., L,ukes I., Peters J.A.
  J. Med. Chem. ,51(3) , (2008), 677-683.

• Pyridine-N-oxide Analogues of DOTA and Their Gadolinium(III) Complexes Endowed with a Fast Water Exchange on the Square-Antiprismatic Isomer (dagger),
  POLÁSEK M, SEDINOVÁ M, KOTEK J, VANDER ELST L, MULLER RN, HERMANN P, LUKES I.
  Inorg Chem., 48, 455-465 , 2008

• Optimization of the Synthesis of Superparamagnetic Contrast Agents by the Design of Experiments Method
  D. FORGE, A. ROCH, S. LAURENT, H. TELLEZ, Y. GOSSUIN, F. RENAUX, L. VANDER ELST, RN. MULLER,
  J. Phys. Chem C, 112 (49), 19178–19185 (2008)

• Molecular imaging of αVβ3  integrin expression in atherosclerotic plaques with a mimetic of RGD peptide grafted to Gd-DTPA.
  Burtea C., Laurent S., Murariu O., Rattat D., Toubeau G., Verbruggen A., Vansthertem D., Vander Elst L., Muller R.N.
  Cardiovasc. res, F.I.:  6,127, (2008), 78, 148-157.

• Paramagnetic liposomes: inner versus outer membranes relaxivity of DPPC liposomes incorporating lipophilic gadolinium complexes.
  Laurent S., Vander Elst L., Thirifays C., Muller R.N.
  Langmuir, F.I.: 4,009, (2008), 24, 4347-4351.

• Relaxivities of paramagnetic liposomes: on the importance of the chain type and the length of the amphiphilic complex.
  Laurent S., Vander Elst L., Thirifays C., Muller R.N.
  Eur. Biophys. J., F.I.:2,238, (2008), 37, 1007-1014.

• Enzymatically prepared n-alkyl esters of glucuronic acid: the effect of freeze-drying conditions and hydrophobic chain length on thermal behavior.
  Blecker C., Danthine S., Pétré M., Lognay G., Moreau B., Vander Elst L., Paquot M., Deroanne C.
  J. Colloid Interf. Sci., F.I.: 2,309, (2008), 321, 154-158.

• Contrast agents: magnetic resonance
  Burtea C., Laurent S., Vander Elst L., Muller R.N.
  Handb. Exp. Pharmacol., (2008), 185, 135-165

• Magnetic labeling of non-phagocytic adherent cells with iron oxide nanoparticles: a comprehensive study,
  S. Boutry, S. Brunin, I. Mahieu, S. Laurent, L. Vander Elst, et R.N. Muller,
  Contrast Media & Molecular Imaging,  3(6), Nov. 2008, p. 223-232

• Synthesis and manifold physicochemical characterization of a new gadolinium complex with a high affinity for human serum albumin
  HENOUMONT C., HENROTTE V., LAURENT S., VANDER ELST L., MULLER R.N.
  J. Inorg. Biochem., F.I.: 2,6540, 2008, 102, 721-30

• Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications.
  Laurent S., Forge D., Port M., Roch A., Robic C., Vander Elst L., Muller R.N.
  Chem. Rev. F.I.:22.757, (2008), 108, 2064-2110.

• Potential amyloid plaque-specific peptides for the diagnosis of Alzheimer's disease.
  Lionel Larbanoix; Carmen Burtea; Sophie Laurent; Fred Van Leuven; Gérard Toubeau; Luce Vander Elst; Robert N. Muller
  Neurobiology of Aging (2008) doi:10.1016/j.neurobiolaging.2008, Nov 21

• Synthesis of a new gadolinium complex with a high affinity for human serum albumin and its manifold physicochemical characterization by proton relaxation rate analysis, NMR diffusometry and electrospray mass spectrometry
  C. Henoumont, V. Henrotte, S. Laurent, L. Vander Elst, R.N. Muller
  J.  Inorg. Biochem., (2008), 102(4): 721-730

• The presence of halide salts influences the non-covalent interaction of MRI contrast agents and human serum albumin
  Henrotte, V; Muller, RN; Bartholet, A, et al.
  Contrast Media & Molecular Imaging, (2007),  2:  258-261

• In vitro characterization of the Gd complex of [2,6-pyridinediylbis(methylene nitrilo)] tetraacetic acid (PMN-tetraacetic acid) and of its Eu analogue, suitable bimodal contrast agents for MRI and optical imaging
  S. Laurent, L. Vander Elst, C. Galaup, R.N. Muller, C. Picard
  Bioorg Med Chem Lett., (2007), 17(22), 6230-6233 FI:2.478

• From phage display to magnetophage, a new tool for magnetic resonance molecular imaging
  J. Segers, C. Laumonier, C. Burtea, S. Laurent, L. Vander Elst, R.N. Muller
  Bioconjug Chem., (2007), 18(4):1251-8

• Comprehensive Investigation of the Non-Covalent Binding of MRI Contrast Agents with Human Serum Albumin
  V. Henrotte, L. Vander Elst, S. Laurent, R.N. Muller
  J. Biol. Inorg. Chem., 929-937 (2007)  FI: 3.224

• A glycosylated complex of gadolinium, a new potential contrast agent for magnetic resonance angiography?
  Yu G, Yamashita M, Aoshima K, Takahashi M, Oshikawa T, Takayanagi H, Laurent S, Burtea C, Vander Elst L, Muller RN.
  Bioorg Med Chem Lett., 17(8), 2246-9 (2007) FI: 2.478

• Hybrid gadolinium oxide nanoparticles : multimodal contrast agents for in vivo imaging
  J.-L. Bridot, A.-C. Faure, S. Laurent, C. Rivière, C. Billotey, B. Hiba, M. Janier, V. Josserand, J.-L. Coll, L. Vander Elst, R.N. Muller, S. Roux, P. Perriat, O. Tillement
  J. Am. Chem. Soc., 129, 5076-5084 (2007) FI: 7.419

• Synthesis and Physicochemical Characterization of New C-functionalized derivatives of Gadolinium 3,6,10-Tris(carboxymethyl)-3,6,10-triazadodecanoate (Gd-TTDA) Exhibiting Fast Water Exchange, Potential Paramagnetic Reporters for Molecular Imaging
  S. Laurent, L. Vander Elst, A. Vroman, R.N. Muller
  Helv. Chim. Acta, 90(3), 562-573 (2007)  FI: 1.650

• Monodisperse Water-Soluble Superparamagnetic Iron Oxide Nanoparticles Revealed as High-Performance T2 Contrast Agents
  J. Qin, S. Laurent, Y. Suk Jo, A. Roch, M. Mikhaylova, R.N. Muller, M. Muhammed
  Adv. Mater.,19, 1874-1878 (2007)  FI: 9.107

• Relaxation by clustered ferritin: a model for ferritin-induced relaxation in vivo.
  Gossuin Y, Gillis P, Muller RN, Hocq A.
  NMR Biomed., 20(8): 749-756 (2007)

• Relaxometric and magnetic characterization of ultrasmall iron oxide nanoparticles with high magnetization. Evaluation as potential T1 magnetic resonance imaging contrast agents for molecular imaging.
  Taboada E, Rodriguez E, Roig A, Oro J, Roch A, Muller RN.
  Langmuir. 2007 Apr 10;23(8):4583-8

• The presence of halide salts influences the non-covalent interaction of MRI contrast agents and human serum albumin
  HENROTTE V., MULLER R.N., BARTHOLET A., VANDER ELST L.
  Contrast Med. Mol. Imaging, 2007, 2, 258-261

• Bis(phenetylamide) derivatives of Gd-DTPA as potential receptor-specific MRI contrast agents
  S. Laurent, T.N. Parac-Vogt, K. Kimpe, C. Thirifays, K. Binnemans, R.N. Muller, L. Vander Elst
  Eur. J. Inorg. Chem., 2061-2067 (2007)  FI:2.514

• Impact of rigidification on relaxometric properties of a tricyclic tetraazatriacetic gadolinium chelate.
  Port M, Raynal I, Vander Elst L, Muller RN, Dioury F, Ferroud C, Guy A.
  Contrast Media Mol Imaging. (2006) May;1(3):121-7.

• Pharmacokinetic and in vivo evaluation of a self-assembled gadolinium(III)-iron(II) contrast agent with high relaxivity
  T.N. Parac-Vogt, L. Vander Elst, K. Kimpe, S. Laurent, C. Burtéa, F. Chen, R. Van Deun, Y. Ni, R.N. Muller, K. Binnemans
  Contrast Med. Mol. Imaging, 1(6), 267-278 (2006)

• A dual lanthanide probe suitable for optical (Tb3+ luminescence) and magnetic resonance imaging (Gd3+ relaxometry)
  N. Geum, I. Nasso, B. Mestre, P. Tisnès, C. Picard, S. Laurent, R.N. Muller, L. Vander Elst
  Bioorg.Med.Chem.Lett.,16, 5309-5312 (2006)

• Comparative study of the physicochemical properties of six clinical low molecular weight gadolinium contrast agents
  S. Laurent, L. Vander Elst, R.N. Muller
  Contrast Med. Mol. Imaging, 1(3), 128-137 (2006)

• Specific E-selectin targeting with a superparamagnetic MRI contrast agent 
  S. Boutry, S. Laurent, L. Vander Elst, R.N. Muller
  Contrast Med. Mol. Imaging, 1(1), 15-22 (2006)

• A new peptidic vector for molecular imaging of apoptosis, identified by phage display technology
  C. Laumonier, J. Segers, S. Laurent, A. Michel, F. Coppée, A. Belayew, L. Vander Elst, R.N. Muller
  J. Biomol. Screening, 11(5), 537-545 (2006)

• Relaxometric Study of Copper [15]Metallacrown-5 Gadolinium Complexes Derived from alpha-Aminohydroxamic Acids
  T.N. Parac-Vogt, A. Pacco, P. Nockemann, S. Laurent, R.N. Muller, M. Wickleder, G. Meyer, L. Vander Elst, K. Binnemans
  Chem Eur J, 12(1):204-210 (2006)

• Paramagnetic liposomes containing amphiphilic bisamide derivatives of Gd-DTPA with aromatic side chain groups as possible contrast agents for magnetic resonance imaging
  PARAC-VOGT T.N., KIMPE K., LAURENT S., PIERAR C., VANDER ELST L., MULLER R. N., BINNEMANS K.
  Eur. Biophys. J., F.I.: 3,2600, 2006, 35, 136-140

• Publications plus anciennes (2000-2005)

• Evaluation of Gd-EOB-DTPA uptake in a perfused and isolated mouse liver model: correlation between magnetic resonance imaging and monochromatic quantitative computed tomography.
  Segers J, Le Duc G, Laumonier C, Tropres I, Elst LV, Muller RN.
  Invest Radiol. 2005 Sep;40(9):574-82.

• The highest water exchange rate ever measured for a Gd(III) chelate. Mato-Iglesias M, Platas-Iglesias C, Djanashvili K, Peters JA, Toth E, Balogh E, Muller RN, Vander Elst L, de Blas A, Rodriguez-Blas T.
  Chem Commun (Camb). 2005 Oct 7;(37):4729-31.
• Looking for biogenic magnetite in brain ferritin using NMR relaxometry. Gossuin Y, Hautot D, Muller RN, Pankhurst Q, Dobson J, Morris C, Gillis P, Collingwood J.
  NMR Biomed. 2005 Nov;18(7):469-72.
• A bisphosphonate monoamide analogue of DOTA: a potential agent for bone targeting.
  Kubicek V, Rudovsky J, Kotek J, Hermann P, Vander Elst L, Muller RN, Kolar ZI, Wolterbeek HT, Peters JA, Lukes I.
  J Am Chem Soc. 2005 Nov 30;127(47):16477-85.
• Relaxivities of human liver and spleen ferritin.
  Gossuin Y, Muller RN, Gillis P, Bartel L.
  Magn Reson Imaging. 2005 Dec;23(10):1001-4.
• Paramagnetic liposomes, inner and outer vesicle relaxivity
  S. Laurent, L. Vander Elst, C. Thirifays, R.N. Muller
  Molecular Imaging, 4(3), 254 (2005)
• A bimodal system (luminophore and paramagnetic contrastophore) derived from Ln(III) complexes based on a bipyridine-containing macrocyclic ligand
  I.Nasso, C. Galaup, F. Havas, P. Tisnes, C. Picard, S. Laurent, L. Vander Elst, R.N. Muller
  Inorg. Chem., 44(23):8293-8305 (2005)
• Paramagnetic liposomes containing amphiphilic bis-amide derivatives of Gd-DTPA with aromatic side chain groups as possible contrast agents for magnetic resonance imaging
  T.N. Parac-Vogt, K. Kimpe, S. Laurent, C. Piérart, L. Vander Elst, R.N. Muller and K. Binnemans,
  Eur. Biophys. J., 35(2):136-44,  (2006)
• Superparamagnetic colloid suspensions : water magnetic relaxation and clustering
  Roch, Y. Gossuin, R.N. Muller, P. Gillis
  J. Magn. Magn. Mater., (2005), 293, 532-539
• C-MALISA (Cellular Magnetic-Linked Immunosorbent Assay), a New Application of Cellular ELISA for MRI    
  C. Burtea, S. Laurent, A. Roch, L. Vander Elst, R.N. Muller
  J. Inorg. Biochem., (2005), 99(5), 1135-1144
• Lanthanide(III) complexes of a mono(methylphosphonate) analogue of H4DOTA: the     influence of protonation of the phosphonate moiety on the TSAP/SAP isomer ratio and the water exchange rate
  J. rudovsky, P. Cigler, J. Kotek, P. Hermann, P. Vojtisek, I. Lukes, J.A. Peters, L. Vander Elst, R.N. Muller
  Chem. Eur. J , (2005), 11, 2373-2384
• In vitro relaxometric and luminescence characterization of P792 (Gadomelitol,       Vistarem®), an efficient and rapid clearance blood pool MRI contrast agent 
  L. Vander Elst, I. Raynal, M. Port, P. Tisnes, R.N. Muller
  Eur. J. Inorg. Chem.,  (2005), 1142-1148
• Relaxation by metal containing nanosystems
  R.N. MULLER,  L. Vander elst, A. Roch, JA. Peters, E. Csajbok, P. Gillis, Y. Gossuin
  Adv. Inorg. Chem., (2005), 57, 239-292
• Synthesis, characterization and pharmacokinetic evaluation of a potential MRI contrast agent containing two paramagnetic centers with albumin binding affinity 
  T.N. Parac-Vogt, K.Kimpe, S. Laurent, L. Vander Elst, C.Burtea, F. Chen, R.N. Muller, Y. Ni, A.Verbruggen, K. Binnemans
  Chem. Eur. J., (2005), 11, 3077-3086
• Structure and Dynamics of Lanthanide Complexes of TTHA and TTHA-bisamides as Studied by NMR, NMRD and EPR 
  E. Zitha-Bovens, R.N. Muller, S. Laurent, L. Vander Elst, C.F.G.C. Geraldes, H van Bekkum, J.A. Peters
  Helv. Chim. Acta, (2005), 88, 618-587
• Is the theoretical fitting of the proton nuclear magnetic relaxation dispersion (NMRD) curves of paramagnetic complexes improved by independent measurement of their self-diffusion coefficients?
  L. Vander Elst, A. Sessoye, S. Laurent, R.N. Muller
  Helv. Chim. Acta, (2005), 88, 574-587
• Magnetic resonance imaging of inflammation with a specific selectin-targeted contrast agent
  S. Boutry, C. Burtea., S. Laurent., L. Vander Elst, R.N. Muller
  Magn. Reson. Med., (2005), 53(4), 800-807
• Lanthanide(III) complexes of a pyridine N-oxide analogue of DOTA: exclusive M isomer formation induced by a six-membered chelate ring 
  M. Polasek, J. Rudovsky, P. Hermann,  I. Lukes, L. Vander Elst, R.N. Muller, Chem.
  Commun., (2004), 22, 2602- 2603
• Investigation of Non Covalent Interactions between Paramagnetic Complexes and Human Serum Albumin by Electrospray Mass Spectrometry   
  V. Henrotte, S. Laurent, V. Gabelica, L. Vander Elst, E. Depauw, R.N. Muller
  Rap. Comm. Mass Spectrom., (2004), 1919-1924
• Optimising the design of paramagnetic MRI contrast agents : influence of backbone substitution on the water exchange rate of Gd-DTPA derivatives 
  S. Laurent, F. Botteman, L. Vander Elst, R.N. Muller
  Magn. Reson. Mat. Phys. Biol. Med., (2004), 16(5), 235-245
• Relaxivity and Transmetallation Stability of New Benzyl-Substituted Derivatives of Gadolinium-DTPA Complexes
  S. Laurent, F. Botteman, L. Vander Elst, R.N. Muller
  Helv Chim Acta, (2004), 87, 1077-1089
• New Bifunctional Contrast Agents: Bis-Amide Derivatives of C-Substituted Gd-DTPA
  S. Laurent, F. Botteman, L. Vander Elst, R.N. Muller
  Eur. J. Inorg. Chem., (2004), 463-468
• Ferritin-induced relaxation in tissues: An in vitro study
  Y. Gossuin, C. Burtea, A. Monseux, G. Toubeau, A. Roch, R.N. Muller, P. Gillis
  J. Magn Reson Imaging (2004), 20 (4): 690-696
• Low-field NMR water proton longitudinal relaxation in ultrahighly diluted aqueous solutions of silica-lactose prepared in glass material for pharmaceutical use
  J.L. Demangeat, P. Gries, B. Poitevin, J.J. Droesbeke, T. Zahaf, F. Maton, C. Pierart, R.N. Muller
  Applied Magnetic Resonance, (2004), 26 (4): 465-481
• Relaxation induced by ferritin: a better understanding for an improved MRI iron quantification
  Y. Gossuin, R.N. Muller, P. Gillis
  NMR in Biomed. (2004), 17 (7): 427-432
• Influence of the length of the coating molecules on the nuclear magnetic relaxivity of superparamagnetic colloids 
  S. Laurent,  A. Ouakssim, C. Nicotra, Y. Gossuin,  A. Roch, L. Vander Elst, M. Cornant,  P. Soleil,  R.N. Muller
  Physica Status Solidi, (2004), 1(12), 3644-3650 
• A gadolinium(III) complex of a carboxylic-phosphorus acid derivative of diethylenetriamine covalently bound to inulin, a potential macromolecular MRI contrast agent.
  P. Lebduskova, J. Kotek, P. Hermann, L. Vander Elst, R.N. Muller, I. Lukes, J.A. Peters
  Bioconjugate Chem., (2004), 15(4), 881-889
• Theoretical investigation into the influence of conformational equilibra on the water-exchange process in magnetic resonance imaging contrast agents 
  U. Cosentino, D. Pitea, G. Moro, V. Barone, A. Villa, R.N. Muller, F. Botteman Theor Chem Acc, (2004), 111, 204-209
• Gadolinium DTPA-monoamide complexes incorporated into mixed micelles as possible MRI contrast agents
  T.N. Parac-Vogt, K. Kimpe, S. Laurent, C. Piérart, L. Vander Elst, R.N. Muller, K. Binnemans
  Eur. J. Inorg. Chem., (2004), 3358-3543
• Magnetic Resonance Molecular Imaging (MRMI) of Early Endothelial Activation in Focal Ischemia in Mice
  P. A. Barber, T. Foniok, D. Kirk, A.M. Buchan, S. Laurent, S. Boutry, R.N. Muller, L. Hoyte, B. Tomanek, U.I. Tuor
  Ann Neurol., (2004), 56(1), 116-120
• MRI detection of early endothelial activation in CNS inflammation
  N.R. Sibson, A.M. Blamire, M. Bernades-Silva, S. Laurent, S. Boutry, R.N. Muller, P.Styles, D.C. Anthony
  Magn Reson. Med, (2004), 51(2), 248-252
• Lanthanide chelates containing pyridine units with potential application as contrast agents in MRI
  C. Platas-Iglesias, M. Mato-Iglesias, K. Djanashhvili, R.N. Muller, L. Vander Elst, J.A. Peters, A. de Blas, T. Rodriguez-Blas
  Chem. Eur. J., (2004), 10(14), 3579-90
• Synthesis and physicochemical characterization of Gd-DTPA-B(sLex)A, a new MRI contrast agent targeted to inflammation 
  S. Laurent, L. Vander Elst, Y. Fu, R.N. Muller
  Bioconjugate Chem., (2004), 15(1), 99-103
• Control of the synthesis of magnetic fluids by relaxometry and magnetometry A. OUAKSSIM, S. FASTREZ, A. ROCH, S. LAURENT, Y. GOSSUIN, C. PIÉRART, L. VANDER ELST, R.N. MULLER
  J. Magn. Magn. Mater., (2004), 272-276, e1711-e1713
• Lanthanide (III) complexes of novel mixed carboxylic phosphorus acid derivativess od diethylenetriamine. A step towards more efficient MRI contrast agents
  J.Kotek, P. Lebduskova, P. Hermann, L. Vander Elst, R.N. Muller, C.F.G.C. Geraldes, T. Maschmeyer, I. Luke, J.A. Peters
  Eur. J. Inorg. Chem., (2003), 9, 5899-5915
• Potential MRI Contrast Agents based on micellar incorporation of amphiphilic bis(alkylamide) derivatives of [(Gd-DTPA)(H2O)]2- 
  K. KIMPE, T.N. PARAC-VOGT, S. LAURENT, C. PIÉRART, L. VANDER ELST, R.N. MULLER, K. BINNEMANS
  Eur. J. Inorg. Chem.,  (2003), 3021-3027
• Stability, Structure and Dynamics of Cationic Lanthanide(III) Complexes of N,N´-Bis(propylamide)ethylenediamine-N,N´-diacetic acid 
  C. PLATAS-IGLESIAS, D.M. CORSI, L. VANDER ELST, R.N. MULLER, C. IMBERT, JCG BÜNZLI, E. TÓTH, T. MASCHMEYER, J.A. PETERS
  J. Chem. Soc. Dalton , (2003), 727-737
• Physicochemical Characterization of P760, a New Macromolecular Contrast Agent with high Relaxivity
  L. VANDER ELST, M. PORT, I. RAYNAL, C. SIMONOT, R.N. MULLER
  Eur. J. Inorg. Chem., (2003), 2495-2501
• Spin Transition Molecular Materials : Intelligent Contrast Agents for Magnetic Resonance  Imaging
  R.N. MULLER, L. VANDER ELST, S. LAURENT
  J. Amer. Chem. Soc., (2003), 125(27), 8405-8407
• Development of new glucosylated derivatives of Gd-DTPA for MRI angiography C. Burtea, S. Laurent,  J-M. Colet, L. Vander Elst, R.N. Muller
  Invest. Radiol., 38(6), 320-333 (2003)
• Anomalous nuclear magnetic relaxation of aqueous solutions of ferritin: An unprecedented    first-order mechanism  
  Y. GOSSUIN, A. ROCH, R.N. MULLER, P. GILLIS, F. LO BUE
  Magn. Reson. Med., (2002), 48(6), 959-964
• An evaluation of the contributions of diffusion and exchange in relaxation enhancement by MRI contrast agents
  Y. GOSSUIN, A. ROCH, R.N. MULLER, P. GILLIS
  J. Magn. Reson., (2002), 158(1-2), 36-42
• Cesium adsorption in hydrated iron oxide particles suspensions: An NMR study.
  Y. GOSSUIN, JM. COLET, A. ROCH, R.N. MULLER, P. GILLIS
  Magn. Reson., (2002), 132-136
• Characterization of Polydisperse Superparamagnetic Particles by Nuclear Magnetic Relaxation Dispersion (NMRD) Profiles
  A. OUAKSSIM, A. ROCH, C. PIERART, R.N. MULLER
  J. Magn. Magn. Mat., (2002), 252, 49-52
• Zeolites GdNaY Nanoparticles with Very High Relaxivities for Applications as Contrast  Agents in Magnetic Resonance Imaging 
  C. PLATAS-IGLESIAS, L. VANDER ELST, W. ZHOU, R.N. MULLER, C.F.G.C. GERALDES, T. MASCHMEYER, J.A. PETERS
  Chem. Eur. J., (2002), 5121-5131
• Synthesis of a Sialyl Lewisx Mimetic Conjugated with DTPA, Potential Ligand of New Contrast Agents for Medical Imaging 
  Y. FU, S. LAURENT, R.N. MULLER
  Eur. J. Org. Chem. , (2002), 3966-3973
• Dy-DTPA derivatives as relaxation agents for very high field MRI: The beneficial effect of slow water exchange on the transverse relaxivities 
  L. VANDER ELST, A. ROCH, P. GILLIS, S. LAURENT, F. BOTTEMAN, J.W.M. BULTE, R.N. MULLER
  Magn. Reson. Med., (2002), 47(6), 1121-1130
• Dy-complexes as high field T-2 contrast agents: Influence of water exchange rates.
  L. VANDER ELST, S. ZHANG, A.D. SHERRY, S. LAURENT, F. BOTTEMAN, R.N. MULLER
  Acad. Radiol., (2002), S297-S299
• Enumeration of Liposomes by multinuclear NMR and photon correlation spectroscopy.
  L. VANDER ELST, C. PIERART, S.L. FOSSHEIM, J.C. RAUX, A. ROCH, R.N. MULLER
  Supramol. Chem., 14(5), 411-417 (2002)
• Synthesis, variable temperature and pressure O-17 NMR study of bis(alkylamide) derivatives of [(Gd-DTPA)(H2O)](2-) - An assessment of the substitution effect on water exchange kinetics 
  F. BOTTEMAN, G.M. NICOLLE, L. VANDER ELST, S. LAURENT, A.E. MERBACH, R.N. MULLER
  Eur J Inorg Chem., 2686-2693 (2002)
• Relaxivity Studies on a Gadolinium(III) Complex of a Macrocyclic DTPA Derivative
  ZITHA-BOVENS E, VANDER ELST L, MULLER RN, VAN BEKKUM H,  PETERS JA Eur. J. Inorg. Chem. 3101-3105 (2001)
• Hepatocyte-mediated Transport to the Bile of AMI-HS, a Particulate Contrast Agent.
  DUPAS B, PRADAL G, MULLER RN, BONNEMAIN B, MEFLAH K, BACH-GANSMO T. Invest Radiol.36 : 509-517 (2001)
• Synthesis, Characterization and Relaxivities of Two Linear Gd(DTPA)-Polymer Conjugates
  M.G. DUARTE, M.H. GIL, J.A. PETERS, J.M. COLET, L.VANDER ELST, R.N. MULLER and C.F.G.C. GERALDES
  Bioconj. Chem. 12 : 170-177 (2001)
• Nuclear Magnetic Relaxation Dispersion of Ferritin and Ferritin-like Magnetic Particle Solutions : a pH-Effect Study
  Y. GOSSUIN, A. ROCH, F. LO BUE, R.N. MULLER, P. GILLIS
  Magn. Reson. Med. 46 : 476-481 (2001)
• Inulin as a Carrier for Contrast Agents in MRI
  D. CORSI, L. VANDER ELST, R.N. MULLER, H. VAN BEKKUM and J.A. PETERS
  Chem. Eur. J. 7 : 64-71 (2001)
• Stability of MRI Paramagnetic Contrast Media. A Proton Relaxometric Protocol for Transmetallation Assessment
  S. LAURENT, L. VANDER ELST, F. COPOIX and R.N. MULLER
  Invest. Radiol. 36 : 115-122 (2001)
• Ultra Small Particulate Iron Oxides as Contrats Agents for Magnetic Resonance Spectroscopy : A Dose-Effect Study
  G. LE DUC, L. VANDER ELST, J-M. COLET, A. ROCH, P. GILLIS, J-F. LEBAS and R.N. MULLER
  J. Magn. Res. Imaging, 13 : 619-626 (2001)
• Slow Clearance Gadolinium Based Extracellular and Intravascular Contrast Media for 3D MR Angiography
  J. BREMERICH, J-M. COLET, S. AIME, K. SCHEFFLER, S. LAURENT, G. BONGARTZ and R.N. MULLER
  J. Magn. Res. Imaging 13 : 588-593 (2001)
• Albumin-Bound MRI Contrast Agents : the Dilemma of the Correlation Time L. VANDER ELST, S. LAURENT, H. MASAKA BINTOMA and R.N. MULLER MAGMA 12 : 134-140 (2001)
• Cesium-133, a Potential Reporter of the Hepatic Uptake of Contrast Agents J-M. COLET, S. LECOMTE, L. VANDER ELST and R.N. MULLER Magn. Reson. Med. (2001)
• Water Relaxation by SPM Particles : neglecting the magnetic anisotropy ? A Caveat.
  ROCH, R.N. MULLER and P. GILLIS
  J. Magn. Res. Imaging 14 : 94-96 (2001)
• Deuterium NMR Study of the MP-2269 : Albumin Interaction ; a Step forward to the Dynamics of Non-Covalent Binding
  K. ADZAMLI, L. VANDER ELST, S. LAURENT and R.N. MULLER
  MAGMA  12 : 92-95 (2001)
• Stereospecific Binding of MRI Contrast Agents to Human Serum Albumin. The case of Gd-(S)-EOB-DTPA (Eovist) and its (â) Isomer
  L. VANDER ELST, F. CHAPELLE, S. LAURENT and R.N. MULLER
  J. Biol. Inorg. Chem. 6 : 196-200 (2001)
• Relaxivity and Water Exchange Studies of a Cationic Macrocyclic Gadolinium (III) Complex
  D. CORSI, L. VANDER ELST, R.N. MULLER, H. VAN BEKKUM and J. PETERS Chem. Eur. J., (2001) (7), 1383-1389
• Relaxation Induced by Ferritin and Ferritin-Like Magnetic Particles: The Role of Proton Exchange
  Y. GOSSUIN, A. ROCH, R.N. MULLER and P. GILLIS
  Magnetic Resonance in Medicine, 43, 237-243 (2000)
• Synthesis and Characterization of Various Benzyl Diethylenetriaminepentaacetic acids (dtpa) and their Paramagnetic Complexes, Potential Contrast Agents for Magnetic Resonance Imaging S. LAURENT, L. VANDER ELST, S. HOUZE, N. GUERIT and R.N. MULLER
  Helvetica Chimica Acta, 83, 394-406 (2000)