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Research

  

The research conducted by the laboratory refers to chemical and biomedical applications of nuclear magnetic resonance (NMR).

While NMR spectroscopy gives access to information of the biochemical type (for example, ATP content), MRI (magnetic resonance imaging) allows researchers to carry out non-invasive examinations of objects, animals and human beings on a sub-millimetre scale.

The lab's instrumentation includes systems of spectroscopy and high-field imagery, all integrated into a powerful data-processing network.

Current research topics include:  

  • Design, synthesis and physicochemical characterisation of paramagnetic and superparamagnetic MRI contrast agents;
  • Study of the pharmacological parameters and the physiological consequences of contrast products and new drugs on isolated and perfused organs in imagery and spectroscopy;
  • Foodstuff characterisation by NMR;
  • Signal processing;
  • Creation of parametric images by fast processing of dynamic data gathered by MRI;
  • Since 2001, the laboratory has been developing a unit of phage display, which is a new technology of High Throughput Screening (HTS) used for identifying peptides targeting the over-expressed cellular receptors in various pathologies. This work has already led to the defence of three doctoral theses which will soon be followed by two more; two patents have been filed. Once grafted onto suitable reporters, selected peptides are used in molecular imagery diagnosis.
  • The peptide vectors selected by phage display can also have therapeutic applications for the targeted diseases, directly or indirectly, thanks to the therapy follow-up with in vitro and/or in vivo tests.